Cinética y Fotoquímica

PEROXIDACION LIPIDICA DE MEMBRANAS BIOLOGICAS

   Se estudia la peroxidación lipídica de membranas naturales, artificiales y lípidos puros en solución mediante el uso de modernas técnicas que permiten medir emisión lumínica: quimioluminiscencia producida durante la formación de radicales peroxilos generados por la destrucción de ácidos grasos polinosaturados presentes en varios tipos de lípidos. Se analiza el efecto de diferentes antioxidantes.

Integrantes del grupo

Coordinador

Dr. Angel Catalá

Colaboradores

Natalia S. Fagali

Principales publicaciones del grupo referidas al proyecto
(2007 - 2011)

* “Lipid peroxidation of membrane phospholipids in the vertebrate retina.”
A. Catalá
Frontiers in bioscience (Scholar edition), 3  , 52-60 (2011).

* “Melatonin and structural analogues do not possess antioxidant properties on Fe²⁺-initiated peroxidation of sonicated liposomes made of retinal lipids.”
N. Fagali y A. Catalá
Chemistry and Physics of Lipids, 164  (7), 688-695 (2011).

* “A synopsis of the process of lipid peroxidation since the discovery of the essential fatty acids.”
A. Catalá
Biochemical and Biophysical Research Communications, 399  (3), 318-323 (2010).

* “The function of very long chain polyunsaturated fatty acids in the pineal gland.”
A. Catalá
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1801  (2), 95-99 (2010).

* “Lipid peroxidation of membrane phospholipids generates hydroxy-alkenals and oxidized phospholipids active in physiological and/or pathological conditions.”
A. Catalá
Chemical Physical Lipids, 157, 1-11 (2009).

* “High resistance to lipid peroxidation of bird heart mitochondria and microsomes: Effects of mass and maximum lifespan.”
A.M. Gutiérrez, G.R. Reboredo, S.M. Mosca y A. Catalá
Comparative Biochemistry and Physiology A-Molecular and Integrative Physiology, 154, 409-416 (2009).

* “Fe²⁺ and Fe³⁺ initiated peroxidation of sonicated and non-sonicated liposomes made of retinal lipids in different aqueous media.”
N. Fagali y A. Catalá
Chemical Physical Lipids, 159, 88-94 (2009).

* “Antioxidant activity of conjugated linoleic acid isomers, linoleic acid and its methyl ester determined by photoemission and DPPH· techniques.”
N. Fagali y A. Catalá
Biophys Chem, 137, 56-62 (2008).

* “An allometric study of fatty acids and sensitivity to lipid peroxidation of brain microsomes and mitochondria isolated from different bird species.”
A.M. Gutierrez, G. Reboredo, S.M. Mosca y A. Catalá
Molecular and Integrative Physiology, 150, 359-365 (2008).

* “Arachidonic acid hydroperoxide stimulates lipid peroxidation on rat liver nuclei and chromatin fractions.”
M. Marmunti y A. Catalá
Molecular and Cellular Biochemistry, 298, 161-168 (2007).

* “Non enzymatic lipid peroxidation of microsomes and mitochondria from liver, heart and brain of the bird Lonchura Striata : relationship with fatty acid composition.”
A.M. Gutierrez, G. Reboredo, S.M. Mosca y A. Catalá
Comparative Biochemistry and Physiology A-Molecular and Integrative Physiology, 146, 415-421 (2007).

* “The effect of melatonin and structural analogues on the lipid peroxidation of triglycerides enriched in ω-3 polyunsaturated fatty acids.”
N. Fagali y A. Catalá
Life Sciences, 81, 299-305 (2007).

* “Melatonin and n-acetyl serotonin inhibit selectively enzymatic and non-enzymatic lipid peroxidation of rat liver microsomes.”
P.J. Leaden y A. Catalá
Prostaglandins Leukot Essent Fatty Acids, 77, 29-35 (2007).

* “The ability of melatonin to counteract lipid peroxidation in biological membranes.”
A. Catalá
Current Molecular Medicine, 7, 638-649 (2007).